Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Toriia, K.; Uozumi, Y.; Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer; RSC Adv.; 2015; 5; 2647-2654

link to article

http://pubs.rsc.org/en/content/articlelanding/2015/ra/c4ra14947e#!divAbstract

We have developed a technique for the aqueous aerobic flow oxidation of alcohols in a continuous-flow reactor containing platinum nanoparticles dispersed on an amphiphilic polystyrene–poly(ethylene glycol) resin (ARP-Pt). Various primary and secondary alcohols including aliphatic, aromatic and heteroaromatic alcohols were efficiently oxidized within 73 seconds in a flowing aqueous system at 100–120 °C under 40–70 bar of the system pressure to give the corresponding carboxylic acids and ketones, respectively, in up to 99% yield. Benzaldehydes could be also prepared selectively from benzyl alcohols by conducting the flow oxidation under the standard conditions in the presence of triethylamine. Moreover, a practical gram-scale synthesis of surfactants was realized in the aqueous aerobic continuous flow oxidation for 36–116 hours. This aerobic flow oxidation system provides a safe, clean, green, rapid and efficient practical method for oxidizing alcohols.

Paper

Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Takao Osako,^a   Kaoru Torii^a and   Yasuhiro Uozumi*^ab  

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Corresponding authors

^a

Institute for Molecular Science (IMS) Myodaiji, Okazaki, Japan
E-mail: uo@ims.ac.jp

^b

RIKEN, Wako, Japan

RSC Adv., 2015,5, 2647-2654

DOI: 10.1039/C4RA14947E
Yasuhiro Uozumi

D.Pharm.

Okazaki, Japan