Sunday 16 March 2014

Aqueous-phase selective hydrogenation of phenol to cyclohexanone over soluble Pd nanoparticles

Aqueous-phase selective hydrogenation of phenol to cyclohexanone over soluble Pd nanoparticles

Green Chem., 2014, Advance Article
DOI: 10.1039/C3GC42408A, Paper
Jing-Fang Zhu, Guo-Hong Tao, Hang-Yu Liu, Ling He, Qian-Hui Sun, Hai-Chao Liu


Corresponding authors
a
College of Chemistry, Sichuan University, Chengdu 610064, China
b
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
c
Kunming Sino-Platinum Metals Catalyst Co., Ltd., Kunming 650101, China

The water-soluble Pd nanoparticles are highly-efficient catalysts for the selective hydrogenation of phenol to cyclohexanone in water under mild conditions.


The water-soluble metal nanoparticles (NPs) stabilized by poly(N-vinyl-2-pyrrolidone) (PVP) were prepared and examined as catalysts for the one-step selective hydrogenation of phenol to cyclohexanone in water. More than 99% conversion of phenol and selectivity to cyclohexanone was obtained at 90 °C and 1 atm H2 for 16 h over “soluble” Pd NPs that were reduced by NaBH4and stabilized by PVP. These Pd NPs were stable, and no leaching or aggregation was detected after five successive runs, showing their advantage for catalyzing the efficient synthesis of cyclohexanone via the one-step selective hydrogenation of phenol under mild conditions.



Saturday 15 March 2014

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Tuesday 11 March 2014

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib



read at
 http://pubs.rsc.org/En/content/articlelanding/2013/ob/c2ob27003j/unauth#!divAbstract


Imatinib (1), nilotinib (2) and dasatinib (3) are Bcr-Abl tyrosine kinase inhibitors approved for the treatment of chronic myelogenous leukemia (CML). This review collates information from the journal and patent literature to provide a comprehensive reference source of the different synthetic methods used to prepare the aforementioned active pharmaceutical ingredients (API's).


Graphical abstract: The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib