Self-contained chemical synthesis

Scientists in the UK have used reactors made on a 3D printer to complete a three stage organic synthesis. The reagents, catalyst and purification step for the synthesis are completely integrated into the chambers of the sealed reactor. When the reactor is rotated, gravity pulls reactants through the different chambers to complete the synthesis.
read all at
http://www.rsc.org/chemistryworld/2013/06/organic-synthesis-reactor-3d-printer

Blog :: DRUG SCALEUP AND MANUFACTURING INTERNATIONAL

Blog :: DRUG SCALEUP AND MANUFACTURING INTERNATIONAL:

'via Blog this'

A Chemical Tripod

Tripod immobilization of ligands is a simple and flexible strategy for creating new heterogeneous catalysts

Read more

A Chemical Tripod

Sustainable Synthesis of Phenols

Phenols synthesized within a few minutes in water with a recyclable deep eutectic solvent
Read more

Baeyer-Villiger oxidation

Also known as: Baeyer-Villiger rearrangement

The Baeyer-Villiger oxidation is an organic reaction used to convert a ketone to an ester using a peroxyacid (such as mCPBA). The reaction of the ketone with the acid results in a tetrahedral intermediate, with an alkyl migration following to release a carboxylic acid. The more electron rich R group migrates to the oxygen in this concerted process, allowing for accurate prediction of the stereochemistry of the product.^[1]
.....................................................................................................................

Mechanism

.......................................................................

References:

1.	Baeyer, A.; Villiger, V. Ber. Dtsch. Chem. Ges. 1899, 32, 3625–3633.

Supercritical Carbon Dioxide: A Promoter of Carbon–Halogen Bond Heterolysis

Supercritical Carbon Dioxide: A Promoter of Carbon–Halogen Bond Heterolysis

Angewandte Chemie International Edition

Volume 52, Issue 50, pages 13298–13301, December 9, 2013

Thais Delgado-Abad, Dr. Jaime Martínez-Ferrer, Prof. Dr. Ana Caballero, Dr. Andrea Olmos, Prof. Dr. Rossella Mello, Prof. Dr. María Elena González-Núñez, Prof. Dr. Pedro J. Pérez and Prof. Dr. Gregorio Asensio

Article first published online: 15 OCT 2013 | DOI: 10.1002/anie.201303819

Amazing reaction medium: Supercritical carbon dioxide, with zero dipole moment, lower dielectric constant than pentane, and non-hydrogen-bonding behavior, ionizes carbon–halogen bonds, dissociates the resulting ion pairs, and escapes from capture by the carbocation intermediates at temperatures above 40 °C. These properties allow the observation of carbocation chemistry in the absence of acids.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201303819/abstract

http://onlinelibrary.wiley.com/store/10.1002/anie.201303819/asset/supinfo/anie_201303819_sm_miscellaneous_information.pdf?v=1&s=1f241331acbea958dddc7b5aa07d5db80210925a

Cheaper Chlorination of Organic Compounds

Inexpensive hydrochloric acid is promising for low-cost electrochemical chlorination
Read more

Cheaper Chlorination of Organic Compounds