Showing posts with label modular flow reactors. Show all posts
Showing posts with label modular flow reactors. Show all posts

Tuesday 16 September 2014

Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis



Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis 

I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.

 http://onlinelibrary.wiley.com/doi/10.1002/chem.200902906/abstract

 Thumbnail image of graphical abstract






Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne[BOND]ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).