Yu and Dai’s C–H activation method overcomes traditional selectivity limitations, activating the C–H bond next door to a powerful directing group (red bonds).
Making Heterocycles Behave In C-H Activation
Organic Chemistry: Reaction overcomes traditional selectivity issues when applied to complex, druglike molecules.read at
http://cen.acs.org/articles/92/i46/Making-Heterocycles-Behave-CH-Activation.html