Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4′-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes

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A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4′-pyridines] in good yields is described here. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4′-pyridine] scaffolds using a double Michael addition/cyclization sequence.

Org. Biomol. Chem., 2015,13, 277-282

DOI: 10.1039/C4OB01959H
http://pubs.rsc.org/en/content/articlelanding/2015/ob/c4ob01959h/unauth#!divAbstract