| From hydrazine and hydrazine derivatives | |
| Hydrazine and hydrazine derivatives are the most common reagents used for the synthesis of phthalazinone derivatives via their reactions with phthalic anhydride, phthalides, phthalimides etc. | |
| Hydrazines with anhydrides: Several methods were reported for the preparation of phthalazinones derivatives. These methods mainly involve the reaction of phthalic anhydrides with hydrazine hydrate in the presence of acetic acid [42-44]. | |
| Phthalazinones 5,7-9 were synthesized from commercially available phthalic anhydride in 2-3 steps as depicted in (Scheme 1 and 2) [45-51]. | |
| Additionally, reaction of phthalic anhydride and aromatic hydrocarbons in the presence of anhydrous aluminum chloride under Friedel-Craft’s conditions afforded 2-aroylbenzoic acids 10 which treated with hydrazine hydrate and hydrazine derivatives to give the phthalazine (2H)-1-one 11,12 [52-57] (Scheme 3). |
| Recent Developments in Chemistry of Phthalazines | ||
| Fatma SM Abu El-Azm*, Mahmoud R Mahmoud, and Mohamed H Hekal | ||
| Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt | ||
| Corresponding Author : | Fatma SM Abu El-Azm Chemistry Department Faculty of Science Ain Shams University, Abbassia Cairo, Egypt, Post code 11566 Tel: 0201220383276 E-mail: ftmsaber@yahoo.com | |
| http://www.omicsonline.org/open-access/recent-developments-in-chemistry-of-phthalazines-2161-0401.1000132.php?aid=40611 | ||
| Citation: El-Azm FSMA, Mahmoud MR, Hekal MH (2015) Recent Developments in Chemistry of Phthalazines. Organic Chem Curr Res 4:132. doi: 10.4172/2161-0401.1000132 | ||
Faculty of Science
Ain Shams University, Abbassia
Cairo, Egypt
/////Phthalazine derivatives, Pyrazolophthalazines, Indazolophthalazines, [1,2,4] Triazolophthalazines, Fatma SM Abu El-Azm
