An efficient Passerini tetrazole reaction (PT-3CR)

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC00910G, Communication

Ajay L. Chandgude, Alexander Domling
A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed.

An efficient Passerini tetrazole reaction (PT-3CR)

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http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00910G?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

An efficient Passerini tetrazole reaction (PT-3CR)

Ajay L. Chandgude^a and   Alexander Dömling*^a  

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Corresponding authors

^a

Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands 
E-mail: a.s.s.domling@rug.nl
Web: http://www.drugdesign.nl/

Green Chem., 2016, Advance Article

DOI: 10.1039/C6GC00910G

 A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed. It comprises the reaction of an aldehyde/ketone, an isocyanide and a TMS-azide in methanol:water (1:1) as the solvent system. The use of sonication not only accelerated the rate of the reaction but also provided good to excellent quantitative yields. This reaction is applicable to a broad scope of aldehydes/ketones and isocyanides.

  
Ajay L. Chandgude

• 
  University of Groningen

  Groningen Research Institute of Pharmacy (GRIP)

  Groningen, Netherlands

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