.
cis (Z) jasmone
(Can.
J. Chem. 1978, Vol 56, p2301)
e.g. How might we attempt to make Z jasmone – an
important constituent of many perfumes?
In fact one synthesis uses the following as carbon
sources:
It is not clear from this however, how the chemistry
might be done! Therefore just being given the starting materials is
not sufficient to help plan a synthesis.
Note the importance of CCBFR.
Note the importance of CCBFR.
We need a logical planning method.
Retrosynthetic Analysis
(The Disconnection Approach)
Originated by E.J. Corey (Nobel Prize 1990)
p169 – 172
p259 – 260
p354 – 359
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