Saturday, 27 June 2015

SiliaMetS Thiol.......A Johnson & Johnson Case Study

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http://www.silicycle.com/products/metal-scavengers/siliamets-metal-scavengers-case-studies/siliamets-customers-successful-stories



Publication: Houpis I.N. & all, Organic Process Research & Development, 13 (2009) p.598
Johnson & Johnson PRD, API Development, Belgium, and Solvias A.G., Synthesis and Catalysis, Switzerland.
In 2009, J&J in collaboration with Solvias published a paper in witch they developed a mild Sonogashira reaction using various metal catalysts. Treatment with SiliaMetS Thiol removed simultanously Pd, Cu & Al. Residual concentrations were respectively < 50, 10, and 3 ppm, in the isolated product 3. Take a look at J&J’s publication for more details.
Note: copper comes from a previous synthesis step.










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Friday, 15 May 2015

Ruthenium-Based Water Oxidation Catalyst



Ruthenium-Based Water Oxidation Catalyst

Non-innocent ligand frameworks for promoting multi-electron reactions
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http://www.chemistryviews.org/details/ezine/7705501/Ruthenium-Based_Water_Oxidation_Catalyst.html

  • Author: Claire D'Andola
  • Published Date: 12 May 2015
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Markus Kärkäs, Rong-Zhen Liao, Björn Åkermark, and co-workers, Stockholm University, Sweden, and Huazhong University of Science and Technology, Wuhan, China, provide an insight into this mechanistic process by using a dinuclear Ru-based WOC.













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