Showing posts with label catalyst-free click reaction. Show all posts
Showing posts with label catalyst-free click reaction. Show all posts

Sunday 8 May 2016

A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

Green Chem., 2016, 18,2642-2646
DOI: 10.1039/C6GC00497K, Communication
Xiaofeng Zhang, Sanjun Zhi, Wei Wang, Shuai Liu, Jerry P. Jasinski, Wei Zhang
A pot-economical synthesis involving two [3 + 2] cycloadditions for diastereoselective synthesis of novel triazolobenzodiazepine-containing polycyclic compounds.
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A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines



A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

Xiaofeng Zhang,a   Sanjun Zhi,b   Wei Wang,c   Shuai Liu,a  Jerry P. Jasinskid and   Wei Zhang*a  
*
Corresponding authors
a
Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, USA 
E-mail: wei2.zhang@umb.edu
b
Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huaian, PR China
c
School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, PR China
d
Department of Chemistry, Keene State College, Keene, USA
Green Chem., 2016,18, 2642-2646

DOI: 10.1039/C6GC00497K





















A pot-economical synthesis involving sequential [3 + 2] cycloadditions of an azomethine ylide and an azide–alkyne (click reaction) has been developed for diastereoselective synthesis of novel triazolobenzodiazepine-containing polycyclic compounds. A new example of catalyst-free click chemistry of non-strained alkynes is also disclosed.







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