Saturday, 27 June 2015

SiliaMetS Thiol.......A Johnson & Johnson Case Study


Publication: Houpis I.N. & all, Organic Process Research & Development, 13 (2009) p.598
Johnson & Johnson PRD, API Development, Belgium, and Solvias A.G., Synthesis and Catalysis, Switzerland.
In 2009, J&J in collaboration with Solvias published a paper in witch they developed a mild Sonogashira reaction using various metal catalysts. Treatment with SiliaMetS Thiol removed simultanously Pd, Cu & Al. Residual concentrations were respectively < 50, 10, and 3 ppm, in the isolated product 3. Take a look at J&J’s publication for more details.
Note: copper comes from a previous synthesis step.


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Quebec City is one of the oldest European settlements in North America. While many of the major cities in Latin America date from the sixteenth century, among ...