The ability to access chemical literature is an important skill for the developing chemist. Although the College of Saint Benedict and Saint John’s University chemistry department had implemented a variety of individual exercises into the introductory course sequence to help students develop literature searching skills, second-year students still struggled with the navigation of the bewildering maze of resources, texts, and databases. This article describes an activity for organic laboratory instructors to coach students on how to prioritize and use a multitude of resources to locate a specific literature procedure. This activity is based on the idea that students find a dialogic approach to be more helpful to consolidate learning and applying knowledge.
Department of Chemistry, College of Saint Benedict and Saint John’s University, Saint Joseph, Minnesota 56374, United States
J. Chem. Educ., 2015, 92 (1), pp 124–126
DOI: 10.1021/ed500486p
Publication Date (Web): October 15, 2014
*E-mail: kgraham@csbsju.edu.
I Will keep updating info on literature search......keep watching
Case study aspirin, acetyl salicylic acid
1 Google
output is
Aspirin - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Aspirin
 | |
 | |
| Systematic (IUPAC) name | |
|---|---|
| 2-(acetoxy)benzoic acid | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682878 |
| Legal status |
|
| Routes | Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously orintramuscularly |
| Pharmacokinetic data | |
| Bioavailability | 80–100%[1] |
| Protein binding | 80–90%[2] |
| Metabolism | Hepatic, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.[2] |
| Half-life | Dose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[2] |
| Excretion | Urine (80–100%), sweat, saliva, feces[1] |
| Identifiers | |
| CAS number | 50-78-2  |
| ATC code | A01AD05 B01AC06,N02BA01 |
| PubChem | CID 2244 |
| DrugBank | DB00945 |
| ChemSpider | 2157 |
| UNII | R16CO5Y76E [FDA] |
| KEGG | D00109 |
| ChEBI | CHEBI:15365 |
| ChEMBL | CHEMBL25 |
| Synonyms | 2-acetoxybenzoic acid acetylsalicylate acetylsalicylic acid O-acetylsalicylic acid |
| PDB ligand ID | AIN (PDBe, RCSB PDB) |
| Chemical data | |
| Formula | C9H8O4 |
| Molecular mass | 180.157 g/mol |
| Physical data | |
| Density | 1.40 g/cm3 |
| Melting point | 136 °C (277 °F) |
| Boiling point | 140 °C (284 °F) (decomposes) |
| 3 mg/mL (20 °C) | |
 (what is this?) (verify) | |
cas no is
| 50-78-2 |
Most of the info in this page is cut paste
2 Check chemspider
CLICK
http://www.chemspider.com/StructureSearch.aspx
DRAW
OUTPUT IS
2-(Acetyloxy)benzoic acid
200-064-1 [EINECS]
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoesäure [German] [ACD/IUPAC Name]
2-Acetoxybenzoic acid [ACD/IUPAC Name]
2-Acetyloxybenzoic acid
2-Carboxyphenyl acetate
50-78-2 [RN] ..................IS THE CAS NUMBER
3 ORGANIC SYNTHESIS
Organic Syntheses
www.orgsyn.org/
CLICK
TYPE TEXT ...ASPIRIN ........ NO HITS
SEARCH TEXT CAS NO OPTION
| 50-78-2 |
MOVE ON
https://pubchem.ncbi.nlm.nih.gov/compound/2244
6 CHEMSYNTHESIS
http://www.chemsynthesis.com/
NO RESULTS
7 eMolecules
http://www.emolecules.com/
8 NIST
http://srdata.nist.gov/gateway/gateway?search=substance
9
MOLBASE
http://www.molbase.com/en/index.html
TYPE ACETYLSALICYCLIC ACID OR
50-78-2
http://www.molbase.com/en/search.html?search_type=text&search_keyword=50-78-2
Synthesis Route (57)
NMR
10 WENKU BAIDU
在线互动式文档分享平台，在这里，您可以和千万网友分享自己手中的文档，全文阅读其他用户的文档，同时，也可以利用分享文档获取的积分下载文档.
Browse and read the wealth of information on the Chinese website Baidu in English. And browse Baidu's search engine in English.
this will be updated please
keep watching everyday.....................
4 SYNARCHIVE
SynArchive - The Organic Synthesis Database
www.synarchive.com/
Find organic syntheses, chemical transformations and named reactions through a growing database of chemical synthesis.- BROWSE MOLECULE.................NO MOLECULE
- BROWSE SYNTHESIS.........NIL
- 5 PUBCHEM
pubchem.ncbi.nlm.nih.gov › NCBI › Chemicals & Bioassays › PubChem
Search By: Name/ Text, Identity/ Similarity, Substructure/ Superstructure, Molecular Formula, 3D Conformer, Saved Search ...
- CLICK
- OUTPUT IS
- MW:
- 180.157420 g/mol
- MF:
- C9H8O4
- IUPAC name:
- 2-acetyloxybenzoic acid
- CID:
- 2244 CLICK TITLE
https://pubchem.ncbi.nlm.nih.gov/compound/2244
6 CHEMSYNTHESIS
http://www.chemsynthesis.com/
NO RESULTS
7 eMolecules
http://www.emolecules.com/
8 NIST
http://srdata.nist.gov/gateway/gateway?search=substance
9
MOLBASE
http://www.molbase.com/en/index.html
TYPE ACETYLSALICYCLIC ACID OR
50-78-2
U WILL GETOUTPUT AS UNDER
Synthesis Route (57)
.........ALL SYNTHESIS ON TOP CENTRE
NMR百度文库——让每个人平等地提升自我
wenku.baidu.com/
Translate this page
Baidu In English
www.baiduinenglish.com/
this will be updated please
keep watching everyday.....................
1 DRUG SYNTHESIS
2 CHEMISTRY BY DESIGN
3 Drug Preparation Database
4 Drugsee.com
5 CHEMSPIDER
6 CHEMSYNTHESIS
7 API DATABASE
8 CHEMISTRY DAILY
9 POPULAR PHARMA DRUGS
10 CHEMNET
11 ORGANIC-REACTION
Home - organic-reaction.com
12 ORGANIC CHEMISTRY.ORG
13 RHODIUM
14 IUPAC
15 Synthesis of Essential Drugs
16 RETYROSYN OF DRUGS
17 Synarchive
SynArchive - Browse syntheses by molecule
18 DRUG DATA
19 VITAMINS
20 DRUGSDB DATABASE
21 HET DRUGS
22 DRUGLEAD
23 ECDYSONE
Ecdybase (The Ecdysone Handbook) - a free online ecdysteroids database. Includes ecdysteroid containing products catalogue.
24
25
.......................................................................................................................
药物合成数据库检索系统
Drug Preparation Database
Drug Preparation Database
| 输入检索的药物名称： | 注：包含通用名、商标名、研发代号、异名等。如Loratadine、Cefpirome. |
| 输入检索的化学名称： | 注：包含CA命名、普通命名等。 |
| 输入检索的CAS登记号： | 注：美国化学文摘登记号。 |
数据库说明:
◆本数据库提供近7000种已上市或在研药物的药物合成相关的信息，如药品名、结构式、化学名、CAS登记号、分子式、分子量、化学活性、开发阶段、研究机构等。最大的优点是快速检索合成路线，并给出参考文献来源。
◆检索条件支持模糊查询，各输入条件间的检索关系为逻辑与（即AND关系）。
◆检索条件选择其一即可查询。
目前本数据库已构建完毕，可提供全部的合成路线文献、结构式及合成路线图。
◆本数据库提供近7000种已上市或在研药物的药物合成相关的信息，如药品名、结构式、化学名、CAS登记号、分子式、分子量、化学活性、开发阶段、研究机构等。最大的优点是快速检索合成路线，并给出参考文献来源。
◆检索条件支持模糊查询，各输入条件间的检索关系为逻辑与（即AND关系）。
◆检索条件选择其一即可查询。
目前本数据库已构建完毕，可提供全部的合成路线文献、结构式及合成路线图。
相关数据库:化学物质索引数据库
DR ANTHONY MELVIN CRASTO Ph.D
MOBILE-+91 9323115463
GLENMARK SCIENTIST , NAVIMUMBAI, INDIADR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now Rpg lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 25 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.His New Drug Approvals , Green Chemistry International, Eurekamoments in Organic Chemistry , Organic Chemistry by Dr Anthony, WIX BLOG , are some most read chemistry blogsHe has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide .
He has good proficiency in Technology Transfer, Spectroscopy , Stereochemistry , Synthesis, Reactions in Org Chem , Polymorphism, Pharmaceuticals , Medicinal chemistry , Organic chemistry literature , Patent related site , Green chemistry , Reagents , R & D , Molecules , Heterocyclic chem , Sourcing etc
He suffered a paralytic stroke in dec 2006 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, amcrasto@gmail.com
He has good proficiency in Technology Transfer, Spectroscopy , Stereochemistry , Synthesis, Reactions in Org Chem , Polymorphism, Pharmaceuticals , Medicinal chemistry , Organic chemistry literature , Patent related site , Green chemistry , Reagents , R & D , Molecules , Heterocyclic chem , Sourcing etc
He suffered a paralytic stroke in dec 2006 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, amcrasto@gmail.com
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 DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE
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