Showing posts with label alkaloids. Show all posts
Showing posts with label alkaloids. Show all posts

Saturday 14 February 2015

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

 
Green Chem., 2015, 17,852-855
DOI: 10.1039/C4GC02325K, Communication

B. R. Lichman,a   E. D. Lamming,b   T. Pesnot,b   J. M. Smith,a  H. C. Hailes*b and   J. M. Ward*a  
 
*Corresponding authors
aDepartment of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London, UK 
bDepartment of Chemistry, University College London, Christopher-Ingold Building, 20 Gordon Street, London, UK 
Green Chem., 2015,17, 852-855

DOI: 10.1039/C4GC02325K


Royal Society of Chemistry


image file: c4gc02325k-s1.tif
 Scheme 1 Overview of the biocatalytic and non-enzymatic cascades presented in this work, including the ‘triangular’ cascade.
image file: c4gc02325k-u1.tif

image file: c4gc02325k-u2.tif

image file: c4gc02325k-s2.tif
 Scheme 2 One-pot chemoenzymatic synthesis of (S)-4 and (S)-5. Reaction conditions: (a) 20 mM 2, 10 mM sodium pyruvate, 500 μg mL−1 NCS and 20% v.v−1 CV2025 lysate, 50 mM HEPES pH 7.5, 37 °C, 3 h. (b) 40 mM formaldehyde, 1 M sodium phosphate, pH 6, 30 min, 37 °C.
 
Prof Helen Hailes
 
 
Appointment
  • Professor of Chemical Biology
  • Dept of Chemistry
  • Faculty of Maths & Physical Sciences
  
 
Research Summary
Research activity in our group is focused on the use of synthetic organic chemistry to probe and solve biological problems. Current projects include the use of water as a reaction solvent and the use of catalytic and biocatalytic synthetic strategies. Also novel kinase inhibitors, cytosine-based hydrogen-bonding polymers and new lipid design for use in a ternary gene delivery vector.
Academic Background
1991PhDDoctor of Philosophy – Organic ChemistryUniversity of Cambridge
1987BABachelor of Arts – Chemistry and MetallurgyUniversity of Cambridge
 
publications..total 146
9 Research Activities
Status