Curtius reaction..........Flow Synthesis

A Modular Flow Reactor for Performing Curtius Rearrangements as a Continuous Flow Process.		Link: 10.1039/b801631n
Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.; Tierney, J. P.
Org. Biomol. Chem. 2008, 6, 1577-1586.
Abstract: The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

http://pubs.rsc.org/en/Content/ArticleLanding/2008/OB/b801631n#!divAbstract

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann,^a   Ian R. Baxendale,^a   Steven V. Ley,*^a  Nikzad Nikbin,^a   Christopher D. Smith^a and   Jason P. Tierney^b  

^a

Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk;
Fax: +44 1223 336442 ;
Tel: +44 1223 336398

^b

Neurology Lead Discovery Chemistry, Neurology CEDD, GlaxoSmithKline R and D, New Frontiers Science Park (North), Third Avenue, Harlow, UK

Org. Biomol. Chem., 2008,6, 1577-1586

DOI: 10.1039/B801631N

Azide Monoliths as Convenient Flow Reactors for Efficient Curtius Rearrangement Reactions.		Link: 10.1039/b801634h
Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N.; Smith, C. D.
Org. Biomol. Chem. 2008, 6, 1587-1593.
Abstract: The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs.

http://pubs.rsc.org/en/Content/ArticleLanding/2008/OB/b801634h#!divAbstract

Azide monoliths as convenient flow reactors for efficient Curtiusrearrangement reactions

Marcus Baumann,^a   Ian R. Baxendale,^a   Steven V. Ley,*^a  Nikzad Nikbin^a and   Christopher D. Smith^a  

^a

Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk;
Fax: +44 1223 336442 ;
Tel: +44 1223 336398

Org. Biomol. Chem., 2008,6, 1587-1593

DOI: 10.1039/B801634H