Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water

 

Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC00313C, Communication

Yu Yang, Sheng Zhang, Lin Tang, Yanbin Hu, Zhenggen Zha, Zhiyong Wang
A water promoted thiolation of indoles with sulfonyl hydrazides has been developed under mild conditions in water.

http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00313C?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

 

A catalyst-free thiolation of indoles with sulfonyl hydrazides was efficiently developed in water under mild conditions without any ligand or additive. The reaction provided a variety of 3-sulfenylindoles with good to excellent yields and the only by-products were nitrogen and water.

 

[1] F.-L. Yang, X.-T. Ma and S.-K. Tian, Chem. Eur. J., 2012, 18, 1582

 

 

 

 

 

Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water

Yu Yang,^a   Sheng Zhang,^a   Lin Tang,^a   Yanbin Hu,^a  Zhenggen Zha^a and   Zhiyong Wang*^a  

 

*Corresponding authors

^aHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, P. R. China
E-mail: zwang3@ustc.edu.cn
Fax: (+86) 551-360-3185

Green Chem., 2016, Advance Article

DOI: 10.1039/C6GC00313C

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