Asymmetric phase transfer catalysis has been recognized as an approach that is greener and more sustainable than synthetic alternatives and has evolved into one of the most practical methods in challenging enantioselective synthesis. An overview of the current status of asymmetric phase transfer catalysis in industry is presented by summarizing research progress from both journal publications and patent applications.

 

Contemporary Asymmetric Phase Transfer Catalysis: Large-Scale Industrial Applications

Jiajing Tan^* and Nobuyoshi Yasuda

Department of Process Chemistry, Merck and Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.5b00304

Publication Date (Web): September 29, 2015

Copyright © 2015 American Chemical Society

*E-mail: jiajing.tan@merck.com.

 http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00304

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