One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

 

Green Chem., 2015, 17,852-855
DOI: 10.1039/C4GC02325K, Communication

B. R. Lichman,a   E. D. Lamming,b   T. Pesnot,b   J. M. Smith,a  H. C. Hailes*b and   J. M. Ward*a  

 

*Corresponding authors

aDepartment of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London, UK 

E-mail: j.ward@ucl.ac.uk

bDepartment of Chemistry, University College London, Christopher-Ingold Building, 20 Gordon Street, London, UK 

E-mail: h.c.hailes@ucl.ac.uk

Green Chem., 2015,17, 852-855

DOI: 10.1039/C4GC02325K

http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C4GC02325K?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

http://pubs.rsc.org/en/content/articlehtml/2015/gc/c4gc02325k

	Scheme 1 Overview of the biocatalytic and non-enzymatic cascades presented in this work, including the ‘triangular’ cascade.

	Scheme 2 One-pot chemoenzymatic synthesis of (S)-4 and (S)-5. Reaction conditions: (a) 20 mM 2, 10 mM sodium pyruvate, 500 μg mL−1 NCS and 20% v.v−1 CV2025 lysate, 50 mM HEPES pH 7.5, 37 °C, 3 h. (b) 40 mM formaldehyde, 1 M sodium phosphate, pH 6, 30 min, 37 °C.

 

Prof Helen Hailes

 

h.c.hailes@ucl.ac.uk

 

Appointment

• Professor of Chemical Biology
• Dept of Chemistry
• Faculty of Maths & Physical Sciences

  

 

Research Groups

• Industrial Biotechnology (BiCE)
• Institute of Biomedical Engineering (IBME)
• Institute of Structural & Molecular Biology, UCL/Birkbeck
• UCL Centre for Chemical Biology

Research Themes

• Synthetic Biology

 

Research Summary

Research activity in our group is focused on the use of synthetic organic chemistry to probe and solve biological problems. Current projects include the use of water as a reaction solvent and the use of catalytic and biocatalytic synthetic strategies. Also novel kinase inhibitors, cytosine-based hydrogen-bonding polymers and new lipid design for use in a ternary gene delivery vector.

Academic Background

1991	PhD	Doctor of Philosophy – Organic Chemistry	University of Cambridge
1987	BA	Bachelor of Arts – Chemistry and Metallurgy	University of Cambridge

 

publications..total 146

https://iris.ucl.ac.uk/iris/browse/profile?upi=HCHAI24

9 Research Activities

Status

 

• BiCE

   

   
• Calixarenes and Tuberculosis Therapies

  Active

   
• Chemoenzymatic and Biocatalytic Synthesis of Aminodiols (BiCE Project)

  Active

   
• Design and Synthesis of Novel Hydrogen Bonding Arrays

  Active

   
• Non-Viral Gene Therapy

  Active

   
• Organic Synthesis in Water

  Active

   
• Synthetic Biology

  Active

   
• The Synthesis of Novel Signaling Molecules

  Active

   
• The synthesis of PI 3-kinase and PKB activators and inhibitors

  Active

  
  

  
  

  UCL LONDON

 

Route Design in the 21st Century: The ICSYNTH Software Tool as an Idea Generator for Synthesis Prediction

The new computer-aided synthesis design tool ICSYNTH has been evaluated by comparing its performance in predicting new ideas for route design to that of historical brainstorm results on a series of commercial pharmaceutical targets, as well as literature data. Examples of its output as an idea generator are described, and the conclusion is that it adds appreciable value to the performance of the professional drug research and development chemist team.

Anders Bøgevig ^‡, Hans-Jürgen Federsel ^*†,Fernando Huerta ^‡, Michael G. Hutchings ^*§, Hans Kraut ^§, Thomas Langer ^†, Peter Löw ^§, Christoph Oppawsky ^§, Tobias Rein ^‡, and Heinz Saller ^§

^† Chemical Development, AstraZeneca R&D, Silk Road Business Park, Macclesfield, SK10 2NA Cheshire, U.K.

^‡ Chemnotia AB, Forskargatan 20 J, 151 36 Södertälje,Sweden

^§ InfoChem GmbH, Landsberger Straße 408/V, D-81241 München, Germany

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/op500373e

Publication Date (Web): January 22, 2015

Copyright © 2015 American Chemical Society

*(H.-J.F.) E-mail: Hans-Jurgen.Federsel@astrazeneca.com., *(M.G.H.) E-mail:mghutchings@infochem.de.

http://pubs.acs.org/doi/full/10.1021/op500373e

Currently, ICSYNTH has assumed a place as a unique predictive tool for route design in Chemical Development in AZ. While it is finding valuable commercial application in our own and others’ hands, it remains a work in progress.

http://infochem.de/

InfoChem’s powerful synthesis planning tool now in Version 2.0. Read more …

InfoChem will be represented at the forthcoming ACS Meeting in San Diego. You will find Dr. Josef Eiblmaier, Dr. Valentina Eigner Pitto, and Dr. Peter Loew …

ICSYNTH

SEE…………….http://www.slideshare.net/Haxel/icic-2014-knowledgebased-de-novo-molecular-design-using-icsynth-frp

http://infochem.de/products/software/icsynth.shtml

http://infochem.de/content/downloads/icsynth.pdf

InfoChem’s ICSYNTH is a powerful computer aided synthesis design tool that enables chemists to generate synthetic pathways for a target molecule. The benefit is that ICSYNTH can facilitate innovation by stimulating ideas for alternative or novel synthetic routes that otherwise may not be considered. This may lead to improved route design, for example shorter pathways or more economical reaction modifications.

After inputting the target, users can select different synthetic strategies depending on requirements. ICSYNTH then automatically generates a multistep interactive synthesis tree – each node on the tree representing a precursor. The advantages are that the suggested reactions are based on, and linked to, published reactions (or their analogs) and the precursor availability is automatically checked in commercial catalogs. Users can modify the synthesis tree or select precursors for further analysis.

At the heart of ICSYNTH is an algorithmic chemical knowledge base of transform libraries that are automatically generated from reaction databases. The number of transform libraries is only limited by the availability of validated reaction databases.
In addition to retro synthesis design, ICSYNTH has a forward reaction prediction module that offers reactivity mapping for the target molecule.Version 2.0 of ICSYNTH was launched in April 2014. The completely re-designed user interface (based on JavaScript) and major improvements in the algorithm responsible of the precursor search are the main enhancements of Version 2.0. In addition the forward reaction prediction algorithm has been optimized. Click here to see a complete version history.

INFOCHEM GESELLSCHAFT FÜR CHEMISCHE INFORMATION MBH

Landsberger Straße 408/V
D-81241 München
Germany

PHONE:	+49 (0)89 58 30 02
FAX:	+49 (0)89 580 38 39
EMAIL:	info@infochem.de

Historische Bilder der Landsberger Straße – An der Trambahnhaltestelle Holzapfelstraße endet – Münchner Straßen – München – Süddeutsche.de

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