Organocatalytic 1,3-dipolar cycloaddition reactions of ketones and azides with water as a solvent

 

Green Chem., 2013, 15,2384-2388
DOI: 10.1039/C3GC41126E, Communication

Dwun Kit Jonathan Yeung,^a   Tao Gao,^b   Jiayao Huang,^a  Shaofa Sun,^b   Haibing Guo^b and   Jian Wang*^a

*

Corresponding authors

^a

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmwangj@nus.edu.sg ;
Fax: (+)65-6516-1691

^b

HuBei Collaborative Innovation Center of Non-power Nuclear Technology, Hubei University of Science and Technology, Hubei Province, China

Received 12 Jun 2013, Accepted 19 Jul 2013
First published online 22 Jul 2013

We reported an enamine catalyzed strategy to fully promote a 1,3-dipolar cycloaddition to access a vast pool of substituted 1,2,3-triazoles in water.