Sunday 10 August 2014

Recent advances in trifluoromethylation of organic compounds using Umemoto's reagents

Recent advances in trifluoromethylation of organic compounds using Umemoto's reagents

Org. Biomol. Chem., 2014, 12,6580-6589
DOI: 10.1039/C4OB00671B, Review Article
Cai Zhang
This review highlights recent developments in the direct introduction of a trifluoromethyl group into organic compounds with Umemoto's reagents

Cai Zhanga  

a
Department of Resources and Environment, Chongqing Vocational Institute of Safety Technology, 583 Anqing Road, Wanzhou District, Chongqing, P. R. China
E-mail: stezh64@163.com;
Fax: (+86)23-58567750 ;
Tel: (+86)23-58567778
Org. Biomol. Chem., 2014,12, 6580-6589

DOI: 10.1039/C4OB00671B


The incorporation of fluorine-containing moieties into organic compounds is of great importance in pharmaceutical, agricultural, and materials science. Within these organofluorides, the trifluoromethyl group is one of the most important motifs. In recent years, the trifluoromethyl group has attracted more and more attention, and many trifluoromethylated compounds have been found to possess special activities. However, until now, only a few methods have been developed to achieve this efficiently using Umemoto's reagents. This review highlights recent developments in the direct introduction of a trifluoromethyl group into organic compounds with Umemoto's reagents. Seven approaches to the trifluoromethylation of organic compounds are summarized: (i) trifluoromethylation of arenes, (ii) trifluoromethylation of alkenes, (iii) trifluoromethylation of terminal alkynes, (iv) deoxygenative trifluoromethylation of benzylic xanthates, (v) trifluoromethylation of ketoesters, (vi) trifluoromethylation of aryl boronic acids and aromatic amines (synthesis of ArCF3) and (vii) trifluoromethylation of biphenyl isocyanide derivatives.

Sunday 3 August 2014

1- Methyl cyclohexene, All about it pictoral




reactions of .above


CAS NO : 1335-86-0
EC NO : 215-640-8
Molecular Formula : C7H12
Main Specifications :
Synonyms : Methyl-1-cyclohexene;1-methylcyclohexene;
1-Methyl-cyclohexene
Molecular Structure:1-Methyl-cyclohexene 1335-86-0




  • Reactants:
    • 2-methylcyclohexan-1-ol
  • Product:
    • 1-methylcyclohexene
  • Type of Reaction:
    • Alkene formation via dehydration






IR



NMR spectrum of 1-methyl-1-cyclohexene.

Source: Spectral Database for Organic Compounds SDBS        http://www.aist.go.jp/RIODB/SDBS/cgi-bin/cre_index.cgi
Assign   Shift(ppm)
  A       5.379
  B       1.96
  C       1.89
  D       1.627
  E       1.61
  F       1.54













Individual Reactions

Hydrogen + Cyclohexene, 1-methyl- = Cyclohexane, methyl-
By formula: H2 + C7H12 = C7H14
QuantityValueUnitsMethodReferenceComment
Δr-111.4 ± 0.37kJ/molChydRogers, Crooks, et al., 1987liquid phase
Δr-106.3 ± 0.46kJ/molChydTurner and Garner, 1958liquid phase; solvent: Acetic acid
Δr-106.3 ± 0.46kJ/molChydTurner and Garner, 1957liquid phase; solvent: Acetic acid

Cyclohexene, 1-methyl- + Trifluoroacetic acid = C9H13F3O3
By formula: C7H12 + C2HF3O2 = C9H13F3O3
QuantityValueUnitsMethodReferenceComment
Δr-36.56 ± 0.88kJ/molCacWiberg, Wasserman, et al., 1985liquid phase; solvent: Trifluoroacetic acid; Trifluoroacetolysis

Cyclohexene, 1-methyl- + Hydrogen chloride = 1-Chloro-1-methylcyclohexane
By formula: C7H12 + HCl = C7H13Cl
QuantityValueUnitsMethodReferenceComment
Δr-56.11 ± 0.88kJ/molCmArnett and Pienta, 1980liquid phase; solvent: Methylene chloride; Hydrochlorination

Cyclohexane, methylene- = Cyclohexene, 1-methyl-
By formula: C7H12 = C7H12
QuantityValueUnitsMethodReferenceComment
Δr-7.2 ± 0.3kJ/molEqkYursha, Kabo, et al., 1974gas phase; Heat of isomerization at 463 K

Cyclohexene, 3-methyl- = Cyclohexene, 1-methyl-
By formula: C7H12 = C7H12
QuantityValueUnitsMethodReferenceComment
Δr-8.1 ± 0.3kJ/molEqkYursha, Kabo, et al., 1974gas phase; Heat of isomerization at 463 K

Cyclohexene, 4-methyl- = Cyclohexene, 1-methyl-
By formula: C7H12 = C7H12
QuantityValueUnitsMethodReferenceComment
Δr-5.8 ± 0.3kJ/molEqkYursha, Kabo, et al., 1974gas phase; Heat of isomerization at 463 K









Alleppey kerala.....Alappuzha

Alappuzha - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Alappuzha
pronunciation (help·info)), also known as Alleppey, is the administrative headquarters of Alappuzha District of Kerala state of southern India. Alappuzha is the ...
 
 
 
 
 
Map of alleppey.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Table in restaurant after eating fish, Alleppey, Kerala, India, South Asia,
 
 
 
 
 
 
 
 
 
 
 
 
 
 PAGODA RESORTS ALLEPPEY KERALA INDIA
 
 
 
 
 
 
 

 
 
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