Palladium-catalyzed acetoxylation of the primary γ-C(sp3)–H bonds in the amino acids Val, Thr, and Ile was achieved using a newly discovered 5-methylisoxazole-3-carboxamide directing group. The γ-acetoxylated α-amino acid derivatives could be easily converted to γ-mercapto amino acids, which are useful for native chemical ligation (NCL). The first application of NCL at isoleucine in the semisynthesis of a Xenopus histone H3 protein was also demonstrated.
5-Methylisoxazole-3-carboxamide-Directed Palladium-Catalyzed γ-C(sp3)–H Acetoxylation and Application to the Synthesis of γ-Mercapto Amino Acids for Native Chemical Ligation
School of Biological Sciences, Nanyang Technological University, Singapore 637551
Org. Lett., 2016, 18 (11), pp 2696–2699
DOI: 10.1021/acs.orglett.6b01160
Publication Date (Web): May 24, 2016
Copyright © 2016 American Chemical Society
*E-mail: cfliu@ntu.edu.sg.
link
Kalyan Kumar Pasunooti,
Experience
Dr. Kalyan Kumar Pasunooti pursued his PhD
degree from Nanyang Technological University (NTU) (www.ntu.edu.sg),
Singapore (2007 – 2011) in the field of Medicinal, Peptide & Protein
chemistry. His graduate research work is focused on “Synthesis of bioactive amino acid building blocks and their
applications towards the peptides and glycopeptides.” His have total 16
years of academic and industry experience with major multinationals companies
& academic institutions and have worked with many collaborative professors
around the globe. He authored with more than 28 international peer-reviewed
high impact publications such as PNAS, Wily (Angew Chemie), RSC (Chem Comm
and Org Biomol Chem), most of
American Chemical Society journals (Journal
of American Chemical Society, Org.
Lett., ACS Chem Bio, J Comb Chem and Bioconugate Chem) and Elsevier (Tetrahedron Letters) journals which
are featured many times in Chem. Eng. News and other journals. He holds American
patent while work with Johns Hopkins-School of Medicine, USA and this molecule
in phase II clinical trials for treating cancer.
Prior to his graduate studies, he spent 5
years as a research scientist in reputable research organizations namely GVK
Bio, India (www.gvkbio.com)
(2006-2007) and Dr. Reddy’s Laboratories Ltd (www.drreddys.com)
(2003-2006) in India. After his PhD graduation, he worked for world leading research
institutes such as Johns Hopkins-School of Medicine, USA (www.hopkinsmedicne.org)
(2012-2013), Nanyang Technological University-NTU, Singapore) (www.ntu.edu.sg)
(2013 – 2017) and Singapore MIT Alliance for research & Technology-SMART (www.smart.mit.edu)
(2017–2018). His research interests focused on development of next generation
biologically relevant peptide & protein therapeutics using their newly
discovered methodologies for biomedical applications.
He has excellent skills in designing
synthesis, purification and characterization of complex peptide and small
molecules for medicinal chemistry applications. He gained extensive experience
in Medicinal, Carbohydrate, Peptide & Protein and nucleotide &
nucleoside Chemistry and familiar with modern methods and experienced in
designing & executing synthesis for various bioactive peptide and small
molecule inhibitors. He well versed in synthesis and characterization of
complex organic molecules and with the analytical data interpretation.
Dr. Kalyan Kumar Pasunooti
Research Scientist at Singapore-MIT Alliance for Research & Technology CentreSingapore'
Accomplished Peptide, Protein and Medicinal chemist with 16 years of academic and industrialexperience in the field of drug discovery and development. Specializations: Peptide & Protein Chemistry,Medicinal Chemistry (Drug Discovery and Development) and Chemical Biology.
Experience
Research Scientist
Company NameSingapore-MIT Alliance for Research & Technology Centre
Dates EmployedJul 2017 – Present
Employment Duration1 yr 4 mos
LocationSingapore
Medicinal Chemistry and Drug Discovery
Research Fellow
Company NameNanyang Technological University, Singapore
Dates EmployedOct 2013 – Jun 2017
Employment Duration3 yrs 9 mos
LocationSingapore
Peptide & Protein Chemistry and Medicinal Chemistry
Postdoctoral Fellow
Company NameJohns Hopkins Medicine
Dates EmployedMay 2012 – Sep 2013
Employment Duration1 yr 5 mos
LocationBaltimore, Maryland Area
Medicinal chemistry, Drug Discovery, Pharmacology and Chemical Biology
Postdoctoral Associate
Company NameNanyang Technological University
Dates EmployedJul 2011 – Mar 2012
Employment Duration9 mos
LocationSingapore
Organic synthesis, Peptide & Carbohydrate chemistry and Medicinal chemistry.
Senior Research Associate in Medicinal Chemistry
Company NameGVK Biosciences
Dates EmployedJan 2007 – Jul 2007
Employment Duration7 mos
LocationHyderabad Area, India
Synthesis of bioactive molecules for medicinal chemistry applications.
Junior Scientist in Medicinal Chemistry (Anti-Infective group)
Company NameDr. Reddy's Laboratories
Dates EmployedAug 2003 – Dec 2006
Employment Duration3 yrs 5 mos
LocationHyderabad Area, India
Medicinal chemistry (Anti-Infective group): My work entails design and synthesis of newoxazolidinone derivatives and new chemical entities as novel antibacterial agents. As a researchscientist my job demanded me to carry out extensive literature survey to design possible syntheticroutes for a proposed molecule and to carry out the total synthetic part in the laborator... See more
Education
Nanyang Technological University
Degree NamePhDField Of StudyOrganic and Bioorganic chemistryDates attended or expected graduation –Osmania University
Degree NameM. ScField Of StudyPhysical Organic ChemistryDates attended or expected graduation –
Kakatiya University
Degree NameB. Sc,Field Of StudyMathematics Physics ChemistryDates attended or expected graduation –
Research Scientist at Singapore-MIT Alliance for Research and Technology
Research Fellow at Nanyang Technological University, Singapore
Former Post-Doctoral Fellow at Johns Hopkins School of Medicine
Studied Physical organic chemistry at PG College of Science, Saifabad/Osmania University
Studied M.P.C at Government Junior College, Hanamkonda
Studied B.Sc. at Kakatiya Government Degree College
Went to Z. P. S. S. Geesugonda
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