Glenmark conferred with Best Biotech New Molecular Entity Patent award « New Drug Approvals:
'via Blog this'
Thursday, 16 January 2014
Saturday, 11 January 2014
The first practical approach to new pyrimido[4,5-d]pyridazines: novel chemoselective and regioselective reactions
| The first practical approach to new pyrimido[4,5-d]pyridazines: novel chemoselective and regioselective reactions (13-7963MP) Arkivoc 2013 Part (iv): General Papers [pp. 323-333] Bahador Karami, Sedigheh Akrami, Saeed Khodabakhshi and S. Setareh Rahmatzadeh Full Text: PDF (325K) |
Bahador Karami,* Sedigheh Akrami, Saeed Khodabakhshi, and S. Setareh Rahmatzadeh
Department of Chemistry, Yasouj University, Yasouj, Zip Code: 75918-74831 P.O.Box 353, Iran
E-mail: karami@mail.yu.ac.ir
Abstract
A new three-component condensation of aryl glyoxals, acetylacetone and urea in the presence of a
small amounts of tungstate sulfuric acid (TSA) leads to novel functionalized 5-acetyl-4-(aryloyl)-
3,4-dihydropyrimidinones which these heterocycles can undergo the Knorr condensation with
hydrazines to produce new pyrimido[4,5-d]pyridazines in good yields. These approaches are
consistent with principles of green chemistry due to some factors, such as the use of a safe and
recyclable catalyst under solvent-free conditions.
Ayatollah Khomeini returns to Iran after 14 years exile on February 1, 1979.
Friday, 10 January 2014
Recent advances on diversity oriented heterocycle synthesis via multicomponent tandem reactions based on A3 coupling
Recent advances on diversity oriented heterocycle synthesis via multicomponent tandem reactions based on A3 coupling (14-8183LR) [pp. 1-20]
Arkivoc 2014 Part (i), 1-20: Special Issue 'Reviews and Accounts'
Yunyun Liu
Full Text: PDF (235K)
http://www.arkat-usa.org/get-file/48824/
Recent advances on diversity oriented heterocycle synthesis via
multicomponent tandem reactions based on A3 coupling
Yunyun Liu*
a,b
a Key Laboratory of Functional Small Organic Molecule, Ministry of Education,
Jiangxi Normal University, Nanchang 330022, P. R. China
b College of Chemistry and Chemical Engineering, Jiangxi Normal University,
Nanchang 330022, P. R. China
A3 coupling reactions are the reactions between aldehydes, amines and alkynes, which yield
propargylamine derivatives under various catalyst conditions. By making use of the versatile
reactivity of propargylamines, tandem reactions initiated by the functional group(s) in the in situ
generated propargylamines constitute one of the most important applications of A3
couplings.
These tandem reactions are especially useful for the synthesis of heterocyclic compounds. In this
review, the progress on multicomponent tandem reactions based on A3
coupling is summarized.
Author’s Biography
Dr. Yunyun Liu was born in 1983 in Shandong Province, China. She obtained her Bachelor
Degree in Qufu Normal University in 2005. She then moved to Zhejiang University to continue
her graduate study in the Department of Chemistry. Under the supervision of Professor Weiliang
Bao, she worked on the field of copper-catalyzed Ullmann coupling reaction and related tandem
reactions for her doctorate study. She obtained her doctorate degree in 2010 and presently she is
an assistant professor in Jiangxi Normal University. She is currently interested in the research of
metal-catalyzed organic synthesis and the development of new cascade organic reactions.
Thursday, 9 January 2014
Self-contained chemical synthesis
Scientists in the UK have used reactors made on a 3D printer to complete a three stage organic synthesis. The reagents, catalyst and purification step for the synthesis are completely integrated into the chambers of the sealed reactor. When the reactor is rotated, gravity pulls reactants through the different chambers to complete the synthesis.
read all at
http://www.rsc.org/chemistryworld/2013/06/organic-synthesis-reactor-3d-printer