Wednesday 14 May 2014

Kinetic Resolution of Diols by Etherification



Kinetic Resolution of Diols by Etherification

Total synthesis of (+)-sacidumlignan D through etherification-based kinetic resolution
Read more

Comparing Catalysts










The selectivity of ligand-capped palladium catalysts in hydrogenation reactions is compared with their lead-poisoned equivalents
Read more

Giant Vesicles from Sophorolipids










Sophorolipids based on linolenic acid self-assemble into giant-vesicle-type structures with membranes similar to those of cell walls
Read more

Oxacycle Synthesis










New approach to synthesis of spirocyclic ethers, aryl ethers, and various oxacycles including oxetanes
Read more

Making Mushroom Molecules









A synthetic route to prepare an unusual tricyclic fungal alkaloid has been developed
Read more

Saturday 19 April 2014

A highly efficient approach to vanillin starting from 4-cresol




Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00003J, Paper
Jian-An Jiang, Cheng Chen, Ying Guo, Dao-Hua Liao, Xian-Dao Pan, Ya-Fei Ji
A highly efficient three-step approach to vanillin has been developed starting from 4-cresol.

A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin.

Oxyhalogenation of thiols and disulfides into sulfonyl chlorides/bromides using oxone-KX (X = Cl or Br) in water




A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides by oxyhalogenation of thiols and disulfides with oxone-KX (X = Cl or Br) using water as the solvent is described.


Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00246F, Paper
Sridhar Madabhushi, Raveendra Jillella, Vinodkumar Sriramoju, Rajpal Singh
A simple and efficient method for synthesis of sulfonyl chlorides/bromides by oxyhalogenation of thiols and disulfides with oxone-KX (X = Cl or Br) using water as the solvent is presented